Current Good Manufacturing Practice Production of an Oncolytic Recombinant Vesicular Stomatitis Viral Vector for Cancer Treatment
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چکیده
منابع مشابه
Oncolytic vesicular stomatitis viruses are potent agents for intravesical treatment of high-risk bladder cancer.
Bladder cancer is the second most common genitourinary malignancy. At initial diagnosis, approximately 70% of cases are non-muscle-invasive; however, current treatment options for superficial disease are of limited efficacy because many patients will develop recurrent tumors. The purpose of this study was to examine two replication-competent oncolytic vesicular stomatitis virus (VSV) strains as...
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In the last decade, we have gained significant understanding of the mechanism by which vesicular stomatitis virus (VSV) specifically kills cancer cells. Dysregulation of translation and defective innate immunity are both thought to contribute to VSV oncolysis. Safety and efficacy are important objectives to consider in evaluating VSV as a therapy for malignant disease. Ongoing efforts may enab...
متن کاملOncolytic immunovirotherapy for melanoma using vesicular stomatitis virus.
Relatively little attention has been paid to the role of virotherapy in promoting antitumor immune responses. Here, we show that CD8+ T cells are critical for the efficacy of intratumoral vesicular stomatitis virus virotherapy and are induced against both virally encoded and tumor-associated immunodominant epitopes. We tested three separate immune interventions to increase the frequency/activit...
متن کاملProduction of Vesicular Stomatitis Virus
In recent years a major thrust in immunology has been to clarify the morphological, surface, and functional properties of the complex populations comprising the lymphoid cell series. At the core of the problem is the mechanism of lymphocyte "activation," the process by which specific antigens or nonspecific agents stimulate resting lymphocytes to transform morphologically (1-5) and to exhibit a...
متن کاملOncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors.
PURPOSE Rhabdoid tumors are highly aggressive pediatric tumors that are usually refractory to available treatments. The purpose of this study was to evaluate the therapeutic potential of two oncolytic viruses, myxoma virus (MV) and an attenuated vesicular stomatitis virus (VSV(DeltaM51)), in experimental models of human rhabdoid tumor. EXPERIMENTAL DESIGN Four human rhabdoid tumor cell lines ...
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ژورنال
عنوان ژورنال: Human Gene Therapy
سال: 2011
ISSN: 1043-0342,1557-7422
DOI: 10.1089/hum.2010.159